DRE
TATA
Altered gene expression
TCDD, ...
Co-activators
Co-repressors
Arnt
AhR
hsp90
mRNA
Changes in protein levels
(e.g., CYPIA1, IL-1$, ...)
Differentiation
and
Proliferation
hsp90
Rb, RelA,…
  HIFa,
Sim,...
chromatin
phosphorylation/
dephosphorylation
Cl
Cl
Cl
Cl
O
O
Cl
Cl
Cl
Cl
O
O
Cl
Cl
Cl
Cl
O
O
Cl
Cl
Cl
Cl
O
O
Arnt
AhR
BTFs
BTFs
hsp90
AIP,..
Transport Mechanism
Other Proteins
AIP,..
hsp90
Mechanism of Action