Body Burdens Associated with Effects
in Animals
2
10
Oxidative stress
0.4 - 17
2.1 - 83
CYP1A2 induction
0.1 - 7
0.6 -33
CYP1A1 induction
BIOCHEM. EFFECTS
0.6 - 16
3.3 - 80
Cancer
4
22
Endometriosis
0.3 - 2
1.6 – 12
Adult immunotoxicity
10
50
Developmental immunotoxicity
0.1 - 8
0.7 –42
Developmental reproductive toxicity
4
22
Developmental Neurotoxicity
(Effect level/current av. US BB, 5ng/kg)
ADVERSE EFFECTS
Margin of Exposure
Body Burden (ng/kg)